(−)-Cytisine (−)-1,[(1R, 5S)-1, 2, 3, 4, 5, 6-hexahydro-1, 5-methano-8H-pyrido [1, 2a][1, 5]
diazocin-8-one (Figure 1), is an alkaloid extracted from various plants belonging to the …

Covering: up to the end of 2011 This review covers classical and modern structural
modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and …

Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute
to decreasing tobacco-related disease. Improved drugs constitute a continued area of study …

Three new (+)-sparteine-like diamines were prepared from (−)-cytisine and evaluated as
sparteine surrogates in the α-lithiation rearrangement of cyclooctene oxide and the …

Nicotinic acetylcholine receptors (nAChRs) are crucial for communication between
synapses in the central nervous system. As such, they are also implicated in several …

Concise and selective: the procedure-controlled synthesis of the title compounds has been
achieved for the first time by an organolithium-promoted convergent tandem annulation …

Novel derivatives of quinolizidine alkaloid (−)-cytisine were synthesised. ADME properties,
cytotoxicity against HEK293 cells and activity against viruses of influenza A/California/07/09 …

Three chiral diamines were synthesised and evaluated as sparteine surrogates in the
lithiation–substitution of N-(tert-butoxycarbonyl) pyrrolidine. The synthesis and attempted …

We report the synthesis and pharmacological properties of several cytisine derivatives.
Among them, two 10-substituted derivatives showed much higher selectivities for the α4β2 …

P-chirogenic phosphine ligands can be prepared via desymmetrization of prochiral
phosphine boranes using s-BuLi·(−)-sparteine complexes. One limitation of this method …