Anatomic pathology studies performed over 150 years ago revealed that excessive
activation of coagulation occurs in the setting of inflammation. However, it has taken over a …

The Hemostatic System as a Modulator of Atherosclerosis | New England Journal of Medicine
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Background Hereditary angioedema is a rare and potentially life-threatening genetic
disease that is associated with kallikrein–kinin system dysregulation. Garadacimab …

Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that
activated platelets release inorganic polyphosphate (polyP), a polymer of 60–100 …

Background The interaction of coagulation factors has been shown to go beyond their
traditional roles in hemostasis and to affect the development of inflammatory diseases. Key …

Abstract Coagulation factor XII (FXII, Hageman factor, EC= 3.4. 21.38) is the zymogen of the
serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced …

Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic,
prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size …

Nueva edición del best seller en fisiología, y el libro más valorado por los estudiantes de
Medicina a la hora de afrontar la asignatura de la Fisiología, uno de los pilares …

Background Hereditary angioedema is associated with dysregulation of the kallikrein–kinin
system. Factor XII (FXII) is a key initiator of the kallikrein–kinin system, which produces …

Human sepsis is thought to be systemic inflammatory response syndrome (SIRS) that is
activated by invasive infection. The multiple organ dysfunction syndrome (MODS) is the …