Excessive blood loss is one of the leading causes of death in trauma, and developing
injectable and antibacterial shape-memory hemostatic materials with high blood absorption …

The contact system, also named as plasma kallikrein-kinin system, consists of three serine
proteinases: coagulation factors XII (FXII) and XI (FXI), and plasma prekallikrein (PK), and …

Activated mast cells trigger edema in allergic and inflammatory disease. We report a
paracrine mechanism by which mast cell-released heparin increases vascular permeability …

This opinion identifies inconsistencies in the generally-accepted surface biophysics involved
in contact activation of blood-plasma coagulation, reviews recent experimental work aimed …

Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is
associated with point mutations in the gene encoding the plasma protease factor XII (FXII) …

C1 inhibitor (C1-INH, also known as SERPING1) can be deficient in plasma as a result of
genetic or acquired conditions, and this causes an episodic, local increase in vascular …

Background Anaphylaxis is an acute, potentially lethal, multisystem syndrome resulting from
the sudden release of mast cell–derived mediators into the circulation. Objectives and …

The human plasma contact system is an immune surveillance system activated by the
negatively charged surfaces of bacteria and fungi and includes the kallikrein-kinin, the …

Aberrant immune responses represent the underlying cause of central nervous system
(CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the …

Compared with vitamin K antagonists, the direct oral anticoagulants (DOACs) are simpler to
administer and are associated with less intracranial bleeding. Nonetheless, even with the …