[HTML][HTML] Emerging nondopaminergic medications for Parkinson's disease: focusing on A2A receptor antagonists and GLP1 receptor agonists

P Shang, M Baker, S Banks, SI Hong… - Journal of Movement …, 2021 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a severe neurodegenerative disease characterized by classic
motor features associated with the loss of dopaminergic neurons and appearance of Lewy …

Pan‐striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine‐dependent incentive …

T Hynes, M Fouyssac, M Puaud, D Joshi… - European Journal of …, 2024 - Wiley Online Library
The emergence of compulsive drug‐seeking habits, a hallmark feature of substance use
disorder, has been shown to be predicated on the engagement of dorsolateral striatal …

A Novel Heuristic Exploration Method Based on Action Effectiveness Constraints to Relieve Loop Enhancement Effect in Reinforcement Learning with Sparse …

Z Ni, Y Jin, P Liu, W Zhao - Cognitive Computation, 2024 - Springer
In realistic sparse reward tasks, existing theoretical methods cannot be effectively applied
due to the low sampling probability ofrewarded episodes. Profound research on methods …

[HTML][HTML] Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain

J Pla-Tenorio, AM Roig, PA García-Cesaní… - Current Research in …, 2023 - Elsevier
The roles of astrocytes as reservoirs and producers of a subset of viral proteins in the HIV
infected brain have been studied extensively as a key to understanding HIV-associated …

Astrocyte adenosine signaling and neural mechanisms of goal-directed and habitual reward-seeking behaviors

S Kang, DS Choi - Neuropsychopharmacology, 2021 - nature.com
While goal-directed behaviors pursue maximized reward through action–outcome
contingency, repeated behaviors often produce invariances between action and outcome …

N6-substituated adenosine analog J4 attenuates anxiety-like behaviors in mice

L Peyton, BE León, H Essa, Y Chern, DS Choi - Psychopharmacology, 2022 - Springer
Rationale Withdrawal from chronic alcohol exposure produces various physical and mental
withdrawal symptoms. Activation of adenosine receptors is known to inhibit withdrawal …

Astrocytes in neural circuits controlling appetite and food intake

KLJ Ellacott - Current Opinion in Endocrine and Metabolic Research, 2022 - Elsevier
The regulation of feeding behaviour is a complex process controlled by neural circuits in the
brain. In addition to neurons, genetic and pharmacological studies in animal models are …

[PDF][PDF] Astrocytes in the external globus pallidus coordinate flexibility of action strategy

SI Hong, S Kang, M Song, M Yang, M Baker, S Kang… - 2021 - scholar.archive.org
The external globus pallidus (GPe) is an integrative hub and gateway for behavioral exibility
in rewardrelated behaviors. However, it remains unknown whether enriched astrocytes in …

Dual role of striatal astrocytes in behavioral flexibility and metabolism in the context of obesity

E Montalban, DHM Chao, A Ansoult, C Pham, A Contini… - bioRxiv, 2023 - biorxiv.org
Brain circuits involved in metabolic control and reward-associated behaviors are potent
drivers of feeding behavior and are both dramatically altered in obesity, a multifactorial …

Astrocytic Bestrophin1 in the Anterior Cingulate Cortex Modulates the Formation and Persistence of Morphine Addiction Memory

L Sun, Z Liu, Y Li, X Lin, Y Huo, S Guo, X Fan, X Ye… - 2024 - researchsquare.com
Emerging evidence indicates that astrocytes play a vital role in both the establishment and
preservation of memories. However, their specific contribution to addiction-related memory …