Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Neutrophil extracellular traps (NETs) are complex structures released by activated
neutrophils during inflammatory responses. Due to their unique potential for causing tissue …

As the world is entering the third year of the COVID-19 pandemic, the discovery of effective
treatments continues to be a global health priority. Despite vaccination success, promising …

Neutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial
proteins, are released by neutrophils in response to pathogens but are also recognized for …

Studies on severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have
highlighted the crucial role of host proteases for viral replication and the immune response …

COVID-19 has been concerning for pregnant women since the beginning of the pandemic,
owing to the risk of severe maternal morbidity and the need for critical care in a population …

Abstract Cathepsin C (CatC, syn. Dipeptidyl peptidase I) is a lysosomal cysteine proteinase
expressed in several tissues including inflammatory cells. This enzyme is important for …

Neutrophil-derived proteases are critical to the pathology of many inflammatory lung
diseases, both chronic and acute. These abundant enzymes play roles in key neutrophil …

Personalised approaches are needed to manage patients with heterogenous condition such
as bronchiectasis and community acquired pneumonia. Inhaled antibiotics (IAB) are widely …

Invading bacterial pathogens are confronted by numerous challenges including harsh
environmental conditions at the site of infection, host immune responses and exposure to …