Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

Spinal cord injury (SCI) causes a permanent neurological disability, and no satisfactory
treatment is currently available. After SCI, pro-nerve growth factor (proNGF) is known to play …

MicroRNAs (miRNAs) play important roles during development and also in adult organisms
by regulating the expression of multiple target genes. Here, we studied the function of miR …

Spinal cord injury (SCI) leads to robust Rho activation at the lesion site. Here, we
demonstrate that BA-210, a cell-permeable fusion protein derived from C3 transferase …

Abstract microRNAs (miRNAs) are a novel class of small non-coding RNAs that negatively
regulate gene expression at the post-transcriptional level. miRNAs can modulate gene …

Myelin integrity is crucial for central nervous system (CNS) physiology while its preservation
and regeneration after spinal cord injury (SCI) is key to functional restoration. Disturbance of …

Background and purpose Alzheimer's disease (AD) is a progressive neurodegenerative
disorder, and Aβ‐induced neuronal damage is the major pathology of AD. There is …

Multipotent adult neural precursor cells (NPCs) have tremendous intrinsic potential to repair
the damaged spinal cord. However, evidence shows that the regenerative capabilities of …

In the brain, specific signalling pathways localized in highly organized regions called niches,
allow the persistence of a pool of stem and progenitor cells that generate new neurons and …