Metastatic cancers are chemoresistant, involving complex interplay between disseminated
cancer cell aggregates and the distant organ microenvironment (extracellular matrix and …

Hostile microenvironment produced by abnormal blood vessels, which is characterized by
hypoxia, low pH value and increasing interstitial fluid pressure, would facilitate tumor …

Invariant natural killer T (iNKT) cells are innate-like T cells that are abundant in liver
sinusoids and play a critical role in tumor immunity. However, the role of iNKT cells in …

Background: Platelets (PLT) have a significant effect in promoting cancer progression and
hematogenous metastasis. However, the effect of platelet activation-related lncRNAs (PLT …

Although angiogenesis inhibitors targeting VEGF/VEGFR2 have been applied for tumor
therapy, the outcomes are still unsatisfactory. Thus, it is urgent to develop novel …

Background Colorectal cancer (CRC) is one of the most common malignancies of the
digestive system, which causes severe financial burden worldwide. However, the specific …

Simple Summary Colorectal cancer is an increasingly prevalent disease that accounts for
substantial mortality and morbidity and is responsible for an impaired quality of life. This …

Purpose: Pancreatic ductal adenocarcinoma (PDA) is a common, deadly cancer that is
challenging both to diagnose and to manage. Its hallmark is an expansive, desmoplastic …

Background Although chronic periodontitis has previously been reported to be linked with
Alzheimer's disease (AD), the pathogenesis between the two is unclear. The purpose of this …

Cancer treatment requires the cooperative efforts of multiple medical specialties. Although
surgeons are often the first specialists to treat the cancer patient, the radiation oncologist …