Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …

The concept of mismatch repair (MMR) was formulated independently in 1964 to explain the
removal of brominated nucleotides from DNA as well as gene conversion during genetic …

We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins,
called hMSH2. Expression of hMSH2 in E. coli causes a dominant mutator phenotype …

DNA mismatch repair (MMR) is an important DNA repair pathway that plays critical roles in
DNA replication fidelity, mutation avoidance and genome stability, all of which contribute …

Like many eukaryotes, bacteria make widespread use of postreplicative DNA methylation for
the epigenetic control of DNA-protein interactions. Unlike eukaryotes, however, bacteria use …

The emergence of mutations in nucleic acids is one of the major factors underlying
evolution, providing the working material for natural selection. Most bacteria are haploid for …

DNA mismatch correction is a strand-specific process involving recognition of
noncomplementary Watson-Crick nucleotide pairs and participation of widely separated …

The single-stranded DNA-binding protein (SSB) of Escherichia coli is involved in all aspects
of DNA metabolism: replication, repair, and recombination. In solution, the protein exists as a …

▪ Abstract The MCM proteins are essential replication initiation factors originally identified as
proteins required for minichromosome maintenance in Saccharomyces cerevisiae. The best …