Bispecific molecules which react both with an Fcy receptor for immunoglobulin G (IgG) of
human effector cells and with either human low density lipoprotein (LDL), or frag ment …

We report that targeting of T cell receptors (TcR) to non‐major histocompatibility complex
(MHC) molecules on thymic cortical epithelial cells by hybrid antibodies in vivo and in fetal …

In development of strategies for immunotberapy of cancer a new emphasis is emerging,
termed T-cell retargeting, which involves artificial redirection of cytotoxic T lymphocytes …

A series of hybrid‐hybridomas were derived by the cell fusion of a CD3 antibody‐secreting
hybridoma with other Ig‐producing cell lines. The Ig molecules secreted by these hybrid …

Interaction of the CD80 (B7‐1) and CD86 (B7‐2) molecules on antigen presenting cells with
the receptors CD28 and CTLA‐4 on T cells generates signals important in the regulation of …

Abstract No. 3278, Mar. 1996.*(73) Assignee: Shanghai CPGuojian Pharmaceutical Guo et
al. Science, vol. 263, pp. 518–520, 1994.* Co., Ltd., Shanghai (CN) Hogan et al. J. Exp …

Hybrid hybridomas (also termed quadromas or tetradomas) are man-made cell lines that
secrete bispecific antibodies (bsAb) with two different specificities being able to crosslink two …

The new approach to the treatment of cancer or to immunomodulation is drug targeting. The
effort to achieve either an absolute or a relative amplification of the tumoricidal effect of …

We report the expression of heterobispecific antibodies (Ab) by transferred genes. The κ and
γ1 genes of a mouse anti-idiotypic Ab (IgG1) were transfected into a mouse hybridoma cell …

We developed a universal recombinant bispecific molecule (BiMol) that is capable of
redirecting cytotoxic T cells to tumor cells via tagged anti‐tumor ligands such as antibody …