Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential
challenge for public health, with a negative impact on the geriatric patient's quality of life …

Autophagy is an intracellular mechanism that maintains cellular homeostasis in different
tissues. This process declines in cartilage due to aging, which is correlated with …

Osteoarthritis (OA) is a common joint disorder with increasing impact in an aging society.
While genetic and transcriptomic analyses have revealed some genes and non-coding loci …

Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …

Background Environmental and endogenous factors under genetic predisposition are
considered to initiate the human intervertebral disc (IVD) degeneration. DNA methylation is …

Identification of changes in epigenetically regulated control mechanisms in joint tissues has
provided novel insight into underlying mechanism of ongoing osteoarthritis disease …

Osteoarthritis (OA) is a common type of arthritis. Chronic inflammation is an important
contributor to the pathogenesis of OA. The maturation and secretion of proinflammatory …

Objectives To compare the epigenetic landscape of 3D cell models of human primary
articular chondrocytes (hPACs) and human bone-marrow derived mesenchymal stem cells …

Introduction Osteoarthritis (OA) is a chronic musculoskeletal disease characterized by
progressive loss of joint function. Historically, it has been characterized as a disease caused …

Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain
and disability. The most severe subtype is erosive hand OA characterized by an abrupt …