A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …

Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune
response associated with immunological memory, provided they display sufficient …

Artificial atoms like the nitrogen vacancy (NV) centers in diamond enable the realization of
fully functional qubits in a solid at room temperature. The functionalities of all the parts …

Autophagy acts as a cellular surveillance mechanism to combat invading pathogens.
Viruses have evolved various strategies to block autophagy and even subvert it for their …

The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular
process capable of degrading various biological molecules (eg, protein, glycogen, lipids …

Background Pancreatic cancer is one of the most lethal malignancies and has an extremely
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …