Sleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is
achieved. We show here that Drosophila glia exhibit a daily cycle of glial mitochondrial …

Degrading pathogenic proteins by degrader technologies such as PROTACs (proteolysis-
targeting chimeras) provides promising therapeutic strategies, but selective degradation of …

Autophagy is a lysosome-dependent, self-renewal mechanism that can degrade and recycle
cellular components in eukaryotic cells to maintain the stability of the intracellular …

STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune
activation upon cGAMP stimulation and is degraded through autophagy. Here, we report that …

Microglia are important immune cells in the central nervous system (CNS) that undergo
turnover throughout the lifespan. If microglial debris is not removed in a timely manner …

During ageing, muscle stem-cell regenerative function declines. At advanced geriatric age,
this decline is maximal owing to transition from a normal quiescence into an irreversible …

Nanomaterials have gained a rapid increase in use in a variety of applications that pertain to
many aspects of human life. The majority of these innovations are centered on medical …

Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid
peroxidation. However, the molecular mechanisms regulating ferroptosis are largely …

African swine fever (ASF) is a highly contagious viral disease of swine which causes high
mortality, approaching 100%, in domestic pigs. ASF is caused by a large, double stranded …

Deep learning algorithms are powerful tools for analyzing, restoring and transforming
bioimaging data. One promise of deep learning is parameter-free one-click image analysis …