Dendritic cells (DCs) are principal defense components that play multifactorial roles in
translating innate immune responses to adaptive immunity in Mycobacterium tuberculosis …

The innate response plays a crucial role in the protection against tuberculosis development.
Moreover, the initial steps that drive the host-pathogen interaction following Mycobacterium …

Altered monocyte differentiation and effector functions characterize immune pathogenesis of
tuberculosis. IL-7 is an important factor for proliferation of T cells and impaired IL-7 sensitivity …

The rampant increase in drug-resistant tuberculosis (TB) remains a major challenge not only
for treatment management but also for diagnosis, as well as drug design and development …

Histone lysine N‑methyltransferase 2C (KMT2C) is involved in transcriptional regulation and
DNA damage repair. Mutations in KMT2C have been implicated in the progression …

Background: Improved diagnostic tests are needed for the early identification of
Mycobacterium tuberculosis-infected young children exposed to an active TB (aTB) index …

As we learnt from the sequence of discoveries that led to the discovery of plasmacytoid
dendritic cells (pDCs), the major physiological function of these cells is assumed to be …

Background: Altered monocyte differentiation and effector functions characterize
tuberculosis pathogenesis. Interleukin-7 (IL-7) mediated T-cell functions are impaired in …

Results Classical monocytes were decreased while intermediate, and nonclassical
monocytes were increased in aTB patients before treatment more than after 2 months of …

Mendelian susceptibility to mycobacterial disease (MSMD) is an inherited predisposition to
infections by Bacille-Calmette Guérin (BCG) vaccine or by environmental mycobacteria. The …