NF-κB: at the borders of autoimmunity and inflammation

L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

Psoriasis pathogenesis and treatment

A Rendon, K Schäkel - International journal of molecular sciences, 2019 - mdpi.com
Research on psoriasis pathogenesis has largely increased knowledge on skin biology in
general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of …

30 years of NF-κB: a blossoming of relevance to human pathobiology

Q Zhang, MJ Lenardo, D Baltimore - Cell, 2017 - cell.com
NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that
time, it has been found to have a broad role in gene induction in diverse cellular responses …

Pathogenesis of psoriasis and development of treatment

E Ogawa, Y Sato, A Minagawa… - The Journal of …, 2018 - Wiley Online Library
The pathogenesis of psoriasis can be explained by dysregulation of immunological cell
function as well as keratinocyte proliferation/differentiation. Recently, the immunological …

The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

PM Brunner, E Guttman-Yassky, DYM Leung - Journal of Allergy and …, 2017 - Elsevier
Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is driven by
both terminal keratinocyte differentiation defects and strong type 2 immune responses. In …

Risankizumab compared with adalimumab in patients with moderate-to-severe plaque psoriasis (IMMvent): a randomised, double-blind, active-comparator-controlled …

K Reich, M Gooderham, D Thaçi, JJ Crowley, C Ryan… - The Lancet, 2019 - thelancet.com
Background Psoriasis is an autoimmune disease that affects approximately 100 million
people worldwide, and is a disease that can be ameliorated by anti-cytokine treatment. We …

Phase 2 trial of selective tyrosine kinase 2 inhibition in psoriasis

K Papp, K Gordon, D Thaçi, A Morita… - … England Journal of …, 2018 - Mass Medical Soc
Abstract Background Tyrosine kinase 2 (TYK2) signaling pathways, which mediate cytokine
signaling, are implicated in the pathophysiology of psoriasis. Selective inhibitors of TYK2 …

The interplay between keratinocytes and immune cells in the pathogenesis of psoriasis

C Albanesi, S Madonna, P Gisondi… - Frontiers in …, 2018 - frontiersin.org
Psoriasis is a chronic inflammatory skin disease resulting from genetic, epigenetic,
environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of …

Regulatory T cells in the treatment of disease

A Sharabi, MG Tsokos, Y Ding, TR Malek… - Nature reviews Drug …, 2018 - nature.com
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …

[HTML][HTML] Focus: skin: current developments in the immunology of psoriasis

F Grän, A Kerstan, E Serfling, M Goebeler… - The Yale journal of …, 2020 - ncbi.nlm.nih.gov
Psoriasis is a frequent inflammatory skin disease. Fundamental research on the
pathogenesis of psoriasis has substantially increased our understanding of skin …