Circulating tumor cell-derived preclinical models: current status and future perspectives

Z Kahounová, M Pícková, S Drápela, J Bouchal… - Cell Death & …, 2023 - nature.com
Despite the advancements made in the diagnosis and treatment of cancer, the stages
associated with metastasis remain largely incurable and represent the primary cause of …

Drug-Free Hybrid Nanoarchitecture Modulation of the Metastatic Behavior of Pancreatic Ductal Adenocarcinoma in Alternative in Vivo Models

A Zamborlin, P Sarogni, V Frusca… - ACS Applied Nano …, 2023 - ACS Publications
Metastasis is the key cause of treatment failure in most oncological patients. The spreading
of cancer cells to distal tissues and organs can be associated with the epithelial-to …

Testing the effects of photobiomodulation on angiogenesis in a newly established CAM burn wound model

B Firouz, L Faihs, P Slezak, N Ghaffari Tabrizi-Wizsy… - Scientific Reports, 2023 - nature.com
Burn wounds are a common challenge for medical professionals. Current burn wound
models hold several limitations, including a lack of comparability due to the heterogeneity of …

A bioconvergence study on platinum-free concurrent chemoradiotherapy for the treatment of HPV-negative head and neck carcinoma

A Gonnelli, P Sarogni, N Giannini… - Artificial Cells …, 2024 - Taylor & Francis
Locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is characterized
by high rate of recurrence, resulting in a poor survival. Standard treatments are associated …

Thermoresponsive keratin-methylcellulose self-healing injectable hydrogel accelerating full-thickness wound healing by promoting rapid epithelialization

K Dixit, H Bora, R Chakrabarti, B Saha, N Dogra… - International Journal of …, 2024 - Elsevier
Chronic wounds suffer from impaired healing due to microbial attack and poor vascular
growth. Thermoresponsive hydrogels gained attention in wound dressing owing to their …

Visualization of vascular perfusion of human pancreatic cancer tissue in the CAM model and its impact on future personalized drug testing

A Ettner-Sitter, A Montagner, J Kuenzel, K Brackmann… - Organoids, 2024 - mdpi.com
Although significant improvements have been made in the treatment of pancreatic cancer, its
prognosis remains poor with an overall 5-year survival rate of less than 10%. New …

[HTML][HTML] A new 3D-printed polylactic acid-bioglass composite for bone tissue engineering induces angiogenesis in vitro and in ovo

S Cichos, E Schätzlein… - … Journal of Bioprinting, 2023 - ncbi.nlm.nih.gov
Large bone defects such as those that occur after trauma or resections due to cancer still are
a challenge for surgeons. Main challenge in this area is to find a suitable alternative to the …

[HTML][HTML] Prostaglandin 15d-PGJ2 inhibits proliferation of lung adenocarcinoma cells by inducing ROS production and activation of apoptosis via sirtuin-1

J Slanovc, M Mikulčić, N Jahn, NGT Wizsy… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Lung adenocarcinoma (LUADC) belongs to the most prevalent and lethal cancer types. As
15-deoxy-Δ12, 14-prostaglandin J 2 (15d-PGJ 2) displays anti-oxidative,-inflammatory, and …

[HTML][HTML] Evaluating the photodynamic efficacy of nebulized curcumin-loaded liposomes prepared by thin-film hydration and dual centrifugation: In vitro and in ovo …

L Bender, AM Ayoub, J Schulze, MU Amin… - Biomaterials …, 2024 - Elsevier
Lung cancer, one of the most common causes of high mortality worldwide, still lacks
appropriate and convenient treatment options. Photodynamic therapy (PDT) has shown …

Danthron, an anthraquinone isolated from a marine fungus, is a new inhibitor of angiogenesis exhibiting interesting antitumor and antioxidant properties

I Vidal, JA Torres-Vargas, JM Sánchez, M Trigal… - Antioxidants, 2023 - mdpi.com
The role played by a sustained angiogenesis in cancer and other diseases stimulates the
interest in the search for new antiangiogenic drugs. In this manuscript, we provide evidence …