mRNA Cancer vaccines: construction and boosting strategies

X Liu, P Huang, R Yang, H Deng - ACS nano, 2023 - ACS Publications
In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …

Emerging platinum (IV) prodrug nanotherapeutics: A new epoch for platinum-based cancer therapy

S Zheng, G Li, J Shi, X Liu, M Li, Z He, C Tian… - Journal of Controlled …, 2023 - Elsevier
Owing to the unique DNA damaging cytotoxicity, platinum (Pt)-based chemotherapy has
long been the first-line choice for clinical oncology. Unfortunately, Pt drugs are restricted by …

NIR‐Activatable Heterostructured Nanoadjuvant CoP/NiCoP Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy and …

C Yang, J Zhang, M Chang, J Tan, M Yuan… - Advanced …, 2024 - Wiley Online Library
Abstract Near‐infrared (NIR) laser‐induced photoimmunotherapy has aroused great interest
due to its intrinsic noninvasiveness and spatiotemporal precision, while immune evasion …

Self-Adjuvanting Polyguanidine Nanovaccines for Cancer Immunotherapy

X Zhang, K Wang, Z Zhao, X Shan, Y Wang, Z Feng… - ACS …, 2024 - ACS Publications
Tapping into the innate immune system's power, nanovaccines can induce tumor-specific
immune responses, which is a promising strategy in cancer immunotherapy. However …

Injectable Nano-in-Gel Vaccine for Spatial and Temporal Control of Vaccine Kinetics and Breast Cancer Postsurgical Therapy

T Liu, X Si, L Liu, S Ma, Z Huang, Y Zhang, W Song… - ACS …, 2024 - ACS Publications
Breast cancer is the most commonly diagnosed cancer, and surgical resection is the first
choice for its treatment. With the development of operation techniques, surgical treatment for …

Stimuli-Responsive mRNA Vaccines to Induce Robust CD8+ T Cell Response via ROS-Mediated Innate Immunity Boosting

L Dong, X Deng, Y Li, X Zhu, M Shu… - Journal of the …, 2024 - ACS Publications
The messenger RNA (mRNA) vaccines hold great significance in contagion prevention and
cancer immunotherapy. However, safely and effectively harnessing innate immunity to …

Advances in cancer vaccine research

N Liu, X Xiao, Z Zhang, C Mao, M Wan… - … Biomaterials Science & …, 2023 - ACS Publications
The use of cancer vaccines is considered a promising therapeutic strategy in clinical
oncology, which is achieved by stimulating antitumor immunity with tumor antigens delivered …

Cancer nanovaccines: nanomaterials and clinical perspectives

N Desai, V Chavda, TRR Singh, ND Thorat, LK Vora - Small, 2024 - Wiley Online Library
Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing
nanotechnology to augment traditional vaccine efficacy. This review comprehensively …

Click‐Chemistry‐Mediated Cell Membrane Glycopolymer Engineering to Potentiate Dendritic Cell Vaccines

H Yang, Z Xiong, X Heng, X Niu, Y Wang… - Angewandte …, 2024 - Wiley Online Library
Dendritic cell vaccine (DCV) holds great potential in tumor immunotherapy owing to its
potent ability in eliciting tumor‐specific immune responses. Aiming at engineering enhanced …

Genetically Engineered Cytomembrane Nanovaccines for Cancer Immunotherapy

Y Pan, X Wu, L Liu, C Zhao, J Zhang… - Advanced …, 2024 - Wiley Online Library
Cancer nanovaccines have attracted widespread attention by inducing potent cytotoxic T
cell responses to improve immune checkpoint blockade (ICB) therapy, while the lack of co …