Introduction During the last 4 decades, registration of patients with primary
immunodeficiencies (PID) has played an essential role in different aspects of these diseases …

The first gene therapy clinical trials were initiated more than two decades ago. In the early
days, gene therapy shared the fate of many experimental medicine approaches and was …

Common variable immunodeficiency is a rare immune deficiency, characterized by low
levels of serum immunoglobulin G, A, and/or M with loss of antibody production. The …

OBJECTIVES: The enteropathy associated with common variable immunodeficiency (CVID)
is poorly characterized, and its possible relationships with well-defined causes of …

BACKGROUND: The 10 warning signs of primary immunodeficiency diseases (PID) have
been promoted by various organizations in Europe and the United States to predict PID …

Purpose A subset of patients with common variable immunodeficiency (CVID) develops
granulomatous and lymphocytic interstitial lung disease (GLILD), a restrictive lung disease …

Abstract Hyper Immunoglobulin M syndrome (HIGM) is a rare primary immunodeficiency
disorder characterized by low or absent levels of serum IgG, IgA, IgE and normal or …

Primary antibody deficiencies (PAD) constitute the majority of all primary immunodeficiency
diseases (PID) and immunoglobulin replacement forms the mainstay of therapy for many …

Common variable immune deficiency (CVID) is the commonest symptomatic primary
immunodeficiency and represents a heterogenous collection of disorders resulting mostly in …

Purpose Few studies have estimated population prevalence and morbidity of primary
immunodeficiency diseases (PIDD). We used administrative healthcare databases to …