[HTML][HTML] LIM kinases, LIMK1 and LIMK2, are crucial node actors of the cell fate: molecular to pathological features
E Villalonga, C Mosrin, T Normand, C Girardin… - Cells, 2023 - mdpi.com
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases
and the only two members of the LIM kinase family. They play a crucial role in the regulation …
and the only two members of the LIM kinase family. They play a crucial role in the regulation …
[HTML][HTML] Cytoskeletal dysregulation and neurodegenerative disease: Formation, monitoring, and inhibition of cofilin-actin rods
AI Wurz, AM Schulz, CT O'Bryant, JF Sharp… - Frontiers in Cellular …, 2022 - frontiersin.org
The presence of atypical cytoskeletal dynamics, structures, and associated morphologies is
a common theme uniting numerous diseases and developmental disorders. In particular …
a common theme uniting numerous diseases and developmental disorders. In particular …
Bisphenol analogues induced social defects and neural impairment in zebrafish
X Mu, Z Liu, X Zhao, L Chen, Q Jia, C Wang, T Li… - Science of The Total …, 2023 - Elsevier
There is evidence in humans that endocrine disrupting chemicals exposure, such as
bisphenol A (BPA), is tied to social behavior impacts when evaluated in early life stage …
bisphenol A (BPA), is tied to social behavior impacts when evaluated in early life stage …
[HTML][HTML] ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease
CE Ramsden, D Zamora, MS Horowitz… - Acta Neuropathologica …, 2023 - Springer
In sporadic Alzheimer's disease (sAD) specific regions, layers and neurons accumulate
hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even …
hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even …
Hippocampal LIMK1-mediated Structural Synaptic Plasticity in Neurobehavioral Deficits Induced by a Low-dose Heavy Metal Mixture
F Zhou, L Ouyang, Q Li, S Yang, S Liu, H Yu, Q Jia… - Molecular …, 2023 - Springer
Humans are commonly exposed to the representative neurotoxic heavy metals lead (Pb),
cadmium (Cd), and mercury (Hg). These three substances can be detected simultaneously …
cadmium (Cd), and mercury (Hg). These three substances can be detected simultaneously …
[HTML][HTML] LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo
R Berabez, S Routier, H Bénédetti, K Plé, B Vallée - Cells, 2022 - mdpi.com
LIM Kinases are important actors in the regulation of cytoskeleton dynamics by controlling
microtubule and actin filament turnover. The signaling pathways involving LIM kinases for …
microtubule and actin filament turnover. The signaling pathways involving LIM kinases for …
[HTML][HTML] Structural aspects of LIMK regulation and pharmacology
Malfunction of the actin cytoskeleton is linked to numerous human diseases including
neurological disorders and cancer. LIMK1 (LIM domain kinase 1) and its paralogue LIMK2 …
neurological disorders and cancer. LIMK1 (LIM domain kinase 1) and its paralogue LIMK2 …
[HTML][HTML] The Multifaceted Role of Cofilin in Neurodegeneration and Stroke: Insights into Pathogenesis and Targeting as a Therapy
This comprehensive review explores the complex role of cofilin, an actin-binding protein,
across various neurodegenerative diseases (Alzheimer's, Parkinson's, schizophrenia …
across various neurodegenerative diseases (Alzheimer's, Parkinson's, schizophrenia …
[HTML][HTML] Synaptic plasticity in schizophrenia pathophysiology
K Zhang, P Liao, J Wen, Z Hu - IBRO neuroscience reports, 2023 - Elsevier
Schizophrenia is a severe neuropsychiatric syndrome with psychotic behavioral
abnormalities and marked cognitive deficits. It is widely accepted that genetic and …
abnormalities and marked cognitive deficits. It is widely accepted that genetic and …