Silicon switch: Carbon–silicon Bioisosteric replacement as a strategy to modulate the selectivity, physicochemical, and drug‐like properties in anticancer …
J Fotie, CM Matherne… - Chemical Biology & Drug …, 2023 - Wiley Online Library
Bioisosterism is one of the leading strategies in medicinal chemistry for the design and
modification of drugs, consisting in replacing an atom or a substituent with a different atom or …
modification of drugs, consisting in replacing an atom or a substituent with a different atom or …
A review on biological and medicinal significance of furan
H Saeid, H Al-sayed, M Bader - AlQalam Journal of Medical …, 2023 - journal.utripoli.edu.ly
An important group of heterocyclic compounds with significant biological characteristics are
furan derivatives. The creation of furan derivatives and their testing for various …
furan derivatives. The creation of furan derivatives and their testing for various …
[HTML][HTML] Design and synthesis of some new furan-based derivatives and evaluation of in vitro cytotoxic activity
New furan-based derivatives have been, designed, synthesized, and evaluated for their
cytotoxic and tubulin polymerization inhibitory activities. DNA flow cytometric study of …
cytotoxic and tubulin polymerization inhibitory activities. DNA flow cytometric study of …
[HTML][HTML] New 3-Aminopropylsilatrane Derivatives: Synthesis, Structure, Properties, and Biological Activity
SN Adamovich, IA Ushakov, EN Oborina… - International Journal of …, 2023 - mdpi.com
The biologically active compound 3-aminopropylsilatrane (a compound with a
pentacoordinated silicon atom) underwent an aza-Michael reaction with various acrylates …
pentacoordinated silicon atom) underwent an aza-Michael reaction with various acrylates …
Investigation of cytotoxic properties of some isoindole-related compounds bearing silyl and azide groups with in vitro and in silico studies
This study aims to evaluate the synthesis of isoindole-1, 3-dione analogues and their
cytotoxic potential. A549 and HeLa cells exposed to 250–100–50–25 µM doses of each …
cytotoxic potential. A549 and HeLa cells exposed to 250–100–50–25 µM doses of each …
The Lacunae identified in processing, analyzing and finding means of catalyst free Oxone mediated through C-3 oxidation of N-alkyl quinoxalin-2(1h)-one
VS Patil, G Chunduri, BK Avasarala… - Synthetic …, 2024 - Taylor & Francis
A catalyst free oxone mediated synthesizing N-alkyl 1, 4-dihydroquinoxaline-2, 3-dione has
been developed by oxidation of the N-alkyl quinoxalin-2 (1 H)-one. The developed method …
been developed by oxidation of the N-alkyl quinoxalin-2 (1 H)-one. The developed method …
[HTML][HTML] Glycoconjugates of Mucochloric Acid—Synthesis and Biological Activity
K Żurawska, D Burdalska, M Skonieczna… - Pharmaceuticals, 2023 - mdpi.com
The pharmacological effects of the presence of a sugar moiety, 1, 2, 3-triazole ring and silyl
groups in the structure of biologically active compounds have been extensively studied in …
groups in the structure of biologically active compounds have been extensively studied in …
Scalable synthesis of biologically active novel ethyl 1-(4-alkyl-3-oxo-3,4-dihydro quinoxaline-2-yl)-1H-pyrazole-4-carboxylate derivatives
VS Patil, S Dhulipala, M Kopperla… - Synthetic …, 2023 - Taylor & Francis
A one pot synthesis of ethyl 1-(1, 2-dihydro-2-oxoquinoxalin-3-yl)-1 H-pyrazole-4-
carboxylate has been developed using the 3-hydrazineylquinoxalin-2 (1 H)-N-alkylation …
carboxylate has been developed using the 3-hydrazineylquinoxalin-2 (1 H)-N-alkylation …
[PDF][PDF] IN SILICO SCREENING BY MOLECULAR DOCKING OF HETEROCYCLIC COMPOUNDS WITH FURAN OR INDOLE NUCLEUS FROM DATABASE FOR …
TK AN - 2024 - academia.edu
Objective: This study aims to perform in silico screening of nine heterocyclic ligands
containing furan or indole with oxygen in their structure selected from the compound …
containing furan or indole with oxygen in their structure selected from the compound …