Marine and terrestrial environments are rich sources of various bioactive substances, which
have been used by humans since prehistoric times. Nowadays, due to advances in chemical …

Skin is the largest non–parenchymal organ of the human body. It constitutes a natural barrier
against pathogens and harmful environmental exposures and contributes to the human …

An organocatalytic Michael/aza-Michael cascade reaction was developed to build the
functionalized quinolizine scaffolds in 60–82% yields, excellent diastereoselectivities, and …

Quinolizidine alkaloids (QAs) are synthesized by the genus Lupinus as a defense against
herbivores. Synthesis of QAs in lupins is species-and organ-specific. Knowledge about their …

Sophora lopecuroides L. is a medicinal plant containing a variety of biologically active
substances, in which alkaloids are the main active substances, and a variety of alkaloids …

Sophoridine (SRP) is a natural quinolizidine alkaloid found in many traditional Chinese
herbs, though its effect on adipose tissue is unclear. We improved serum lipid levels by …

A phytochemical investigation on the alkaloid fractions of Sophora alopecuroides L. led to
the production of 11 undescribed matrine-type alkaloids, sophaloseedlines I–S (1− 11), 12 …

Four undescribed ent-kaurane diterpenoids, wilkaunoids A− D (1–4), and three undescribed
abietane diterpenoids, wilabinoids A− C (13–15), along with thirteen known ones (5–12 and …

1 湖南中医药大学, 长沙410013; 2 湖南中医药大学第一附属医院; 3 湖南省儿童医院药学部,
长沙410007 摘要: 为明确百蕊草醇提物中的化学成分, 本研究采用超高效液相色谱-四极杆 …

Background: Topoisomerase I (Topo I) is a key target of many antitumor drugs in vivo.
Alkaloids in Sophora alopecuroides L. can reportedly inhibit Topo I activity, but the …