Reactive oxygen species (ROS) are important second messengers in many metabolic
processes and signaling pathways. Disruption of the balance between ROS generation and …

This review focuses on the potential ameliorative effects of polyphenolic compounds derived
from human diet on hepatic diseases. It discusses the molecular mechanisms and recent …

High dietary intake of dietary polyphenols is associated with a decreased risk of chronic
diseases, especially in inflammation. However, mechanisms responsible for their anti …

Reactive oxygen species (ROS) are radical oxygen intermediates that serve as important
second messengers in signal transduction. However, when the accumulation of these …

Reference genes are obligatory for accurate normalization of mRNA transcript levels across
samples and experimental conditions in Real Time-polymerase chain reaction (qRT-PCR) …

Resveratrol has long been proposed as being beneficial to human health across multiple
morbidities, yet there is currently no conclusive clinical evidence to advocate its …

Drosophila melanogaster is a valuable model organism for a wide range of biological
exploration. The well-known advantages of D. melanogaster include its relatively simple …

Impaired iron metabolism has been increasingly observed in many diseases, but a deeper,
mechanistic understanding of the cellular impact of altered iron metabolism is still lacking. In …

Non-alcoholic fatty liver disease (NAFLD) encompasses hepatic steatosis, non-alcoholic
steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. It is the primary …

Objectives Phloretin is ubiquitous in apples (Malus domestica) and other fruits and has
potential antidiabetic properties. Considering the preclinical potential of phloretin, its …