Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action

FX Heinz, K Stiasny - npj Vaccines, 2021 - nature.com
COVID-19 vaccines were developed with an unprecedented pace since the beginning of the
pandemic. Several of them have reached market authorization and mass production …

Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

[PDF][PDF] LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

K Westendorf, S Žentelis, L Wang, D Foster… - Cell reports, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal
antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 …

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

RE Chen, ES Winkler, JB Case, ID Aziati, TL Bricker… - Nature, 2021 - nature.com
Rapidly emerging SARS-CoV-2 variants jeopardize antibody-based countermeasures.
Although cell culture experiments have demonstrated a loss of potency of several anti-spike …

Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants

E Andreano, I Paciello, G Piccini, N Manganaro… - Nature, 2021 - nature.com
The emergence of SARS-CoV-2 variants is jeopardizing the effectiveness of current
vaccines and limiting the application of monoclonal antibody-based therapy for COVID-19 …

SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine

R Kotaki, Y Adachi, S Moriyama, T Onodera… - Science …, 2022 - science.org
Multiple SARS-CoV-2 variants have mutations in the spike receptor binding domain (RBD)
with potential to evade neutralizing antibody. In particular, the Beta and Omicron variants …

A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination

G Zhang, Y Cong, FL Liu, J Sun, J Zhang, G Cao… - Nature …, 2022 - nature.com
The global emergency caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and …

Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID‐19 vaccines in Hong Kong

CKP Mok, CA Cohen, SMS Cheng, C Chen… - …, 2022 - Wiley Online Library
Background and objective Few head‐to‐head evaluations of immune responses to different
vaccines have been reported. Methods Surrogate virus neutralization test (sVNT) antibody …

SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma

E Andreano, G Piccini, D Licastro… - Proceedings of the …, 2021 - National Acad Sciences
To investigate the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) in the immune population, we coincupi bated the authentic virus with a highly neutralizing …

[PDF][PDF] Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants

S Moriyama, Y Adachi, T Sato, K Tonouchi, L Sun… - Immunity, 2021 - cell.com
Antibody titers against SARS-CoV-2 slowly wane over time. Here, we examined how time
affects antibody potency. To assess the impact of antibody maturation on durable …