Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been
implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease commonly
diagnosed among the elderly population. AD is characterized by the loss of synaptic …

DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …

Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
forms an inflammasome with apoptosis-associated speck-like protein containing a CARD …

Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia.
The importance of negative regulation of NLRP3 inflammasomes remains poorly …

The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to
maturation of interleukin-1β (IL-1β) and IL-18 and induction of proinflammatory cell death in …

Nucleotide-binding and leucine-rich repeat (NLR) proteins are critical intracellular immune
receptors in both animals and plants. Perception of pathogen-derived or stress-associated …

The NLRP3 inflammasome is a critical component of the innate immune system. NLRP3
activation is induced by diverse stimuli associated with bacterial infection or tissue damage …

Responding to stimuli, nucleotide-binding domain and leucine-rich repeat–containing
proteins (NLRs) oligomerize into multiprotein complexes, termed inflammasomes, mediating …

The role of the PYHIN family member absent in melanoma 2 (AIM2), another important
inflammasome sensor, in EAE remains unclear. In this study, we found that AIM2 negatively …