Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications

J Zielonka, J Joseph, A Sikora, M Hardy… - Chemical …, 2017 - ACS Publications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

M Kolarikova, B Hosikova, H Dilenko… - Medicinal Research …, 2023 - Wiley Online Library
Photodynamic therapy is an alternative treatment mainly for cancer but also for bacterial
infections. This treatment dates back to 1900 when a German medical school graduate …

Piezocatalytic 2D WS2 Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism …

Q Truong Hoang, KA Huynh… - Advanced …, 2023 - Wiley Online Library
Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by
piezoelectric polarization under an external mechanical force have emerged as an effective …

Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

L Jiang, S Zhou, X Zhang, C Li, S Ji, H Mao… - Nature …, 2021 - nature.com
The mitochondrion is an important sub-cellular organelle responsible for the cellular
energetic source and processes. Owing to its unique sensitivity to heat and reactive oxygen …

Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

J Yang, A Griffin, Z Qiang, J Ren - Signal transduction and targeted …, 2022 - nature.com
Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

[HTML][HTML] Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives

G Battogtokh, YS Choi, DS Kang, SJ Park… - … Pharmaceutica Sinica B, 2018 - Elsevier
Mitochondrial targeting is a promising approach for solving current issues in clinical
application of chemotherapy and diagnosis of several disorders. Here, we discuss direct …

Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy

X Guo, X Wei, Z Chen, X Zhang, G Yang… - Progress in Materials …, 2020 - Elsevier
To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …

Smart Design of Nanomaterials for Mitochondria‐Targeted Nanotherapeutics

SS Liew, X Qin, J Zhou, L Li, W Huang… - Angewandte Chemie …, 2021 - Wiley Online Library
Mitochondria are the powerhouse of cells. They are vital organelles that maintain cellular
function and metabolism. Dysfunction of mitochondria results in various diseases with a …

Regulating Photosensitizer Metabolism with DNAzyme-Loaded Nanoparticles for Amplified Mitochondria-Targeting Photodynamic Immunotherapy

X Zhao, H Cheng, Q Wang, W Nie, Y Yang, X Yang… - ACS …, 2023 - ACS Publications
Mitochondria-specific photosensitizer accumulation is highly recommended for
photodynamic therapy and mitochondrial DNA (mtDNA) oxidative damage-based innate …