Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

Many advances have been made in the diagnosis and management of heart failure (HF) in
recent years. Cardiac biomarkers are an essential tool for clinicians: point of care B-type …

The sarcomeric titin springs influence myocardial distensibility and passive stiffness. Titin-
isoform composition and protein kinase-A-dependent titin phosphorylation are variables …

Over the past few years, a wealth of biochemical and functional data have been gathered on
mammalian cGMP-dependent protein kinases (cGKs). In mammals, three different kinases …

Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling
intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic …

A current challenge in cellular signaling is to decipher the complex intracellular
spatiotemporal organization that any given cell type has developed to discriminate among …

Signaling cascades initiated by nitric oxide (NO) and natriuretic peptides (NPs) play an
important role in the maintenance of cardiovascular homeostasis. It is currently accepted that …

Cardiac natriuretic peptides (NP) are major activators of human fat cell lipolysis and have
recently been shown to control brown fat thermogenesis. Here, we investigated the …

The natriuretic peptide (NP) system is an important endocrine, autocrine and paracrine
system, consisting of a family of peptides which provide cardiac, renal and vascular effects …

Background—Cyclic guanosine monophosphate (cGMP) is the common second messenger
for the cardiovascular effects of nitric oxide (NO) and natriuretic peptides, such as atrial or …