The redox states of the NAD and NADP pyridine nucleotide pools play critical roles in
defining the activity of energy producing pathways, in driving oxidative stress and in …

The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet
their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the …

Mitochondria play a pivotal role in energy metabolism, programmed cell death and oxidative
stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key …

The negative impact of obesity on reproductive success is well documented but the stages at
which development of the conceptus is compromised and the mechanisms responsible for …

Optical microscopic imaging offers opportunities to perform noninvasive assessments of
numerous parameters associated with the biochemistry, morphology, and functional state of …

The non-invasive high-resolution spatial mapping of cell metabolism within tissues could
provide substantial advancements in assessing the efficacy of stem cell therapy and …

The existence of hypoxia-induced reactive oxygen species (ROS) production remains
controversial. However, numerous observations with a variety of methods and in many cells …

We have developed genetically encoded fluorescent sensors for reduced nicotinamide
adenine dinucleotide (NADH), which manifest a large change in fluorescence upon NADH …

Reactive oxygen species (ROS) formation and signaling are of major importance and
regulate a number of processes in physiological conditions. A disruption in redox status …

The pyridine nucleotides, NAD+ and NADH, are coenzymes that provide oxidoreductive
power for the generation of ATP by mitochondria. In skeletal muscle, exercise perturbs the …