RNA‐binding proteins, neural development and the addictions

CD Bryant, N Yazdani - Genes, Brain and Behavior, 2016 - Wiley Online Library
Transcriptional and post‐transcriptional regulation of gene expression defines the
neurobiological mechanisms that bridge genetic and environmental risk factors with …

Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders

MA Gillentine, T Wang, K Hoekzema, J Rosenfeld… - Genome medicine, 2021 - Springer
Background With the increasing number of genomic sequencing studies, hundreds of genes
have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery …

Respiration-deficient astrocytes survive as glycolytic cells in vivo

LM Supplie, T Düking, G Campbell, F Diaz… - Journal of …, 2017 - Soc Neuroscience
Neurons and glial cells exchange energy-rich metabolites and it has been suggested,
originally based on in vitro data, that astrocytes provide lactate to glutamatergic synapses …

Imaging mRNA and protein interactions within neurons

C Eliscovich, SM Shenoy… - Proceedings of the …, 2017 - National Acad Sciences
RNA–protein interactions are essential for proper gene expression regulation, particularly in
neurons with unique spatial constraints. Currently, these interactions are defined …

Sorting mRNA molecules for cytoplasmic transport and localization

N Neriec, P Percipalle - Frontiers in Genetics, 2018 - frontiersin.org
In eukaryotic cells, gene expression is highly regulated at many layers. Nascent RNA
molecules are assembled into ribonucleoprotein complexes that are then released into the …

Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons

N Fukuda, T Fukuda, P Percipalle, K Oda, N Takei… - Cell reports, 2023 - cell.com
Spatiotemporal control of gene expression is important for neural development and function.
Here, we show that heterogeneous nuclear ribonucleoprotein (hnRNP) A/B is highly …

Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b

W Li, W Shen, B Zhang, K Tian, Y Li, L Mu, Z Luo… - Protein & …, 2020 - academic.oup.com
The mechanisms underlying spatial and temporal control of cortical neurogenesis of the
brain are largely elusive. Long non-coding RNAs (lncRNAs) have emerged as essential cell …

N-cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions

M Klingener, M Chavali, J Singh… - Journal of …, 2014 - Soc Neuroscience
Discrete cellular microenvironments regulate stem cell pools and their development, as well
as function in maintaining tissue homeostasis. Although the signaling elements modulating …

The N6‐methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion …

M Xu, B Li, J Huang, R Jia, J Guo - International Endodontic …, 2023 - Wiley Online Library
Aim Fat mass and obesity‐associated (FTO) protein, the first discovered N6‐methyladenine
(m6A) demethylase, played positive roles in bone formation. In this study, the aim was to …

A conserved function in phosphatidylinositol metabolism for mammalian Vps13 family proteins

JS Park, S Halegoua, S Kishida, AM Neiman - PloS one, 2015 - journals.plos.org
The Vps13 protein family is highly conserved in eukaryotic cells. In humans, mutations in the
gene encoding the family member VPS13A lead to the neurodegenerative disorder chorea …