Porphyromonas endodontalis lipopolysaccharide (Pe LPS) is an important initiating factor
for periapical inflammation and bone destruction. Matrix metalloproteinase-13 (MMP-13) has …

Histone acetyltransferases (HATs) catalyze the acetylation of specific lysine residues in
histone and nonhistone proteins. Recent studies showed that acetylation is widely …

Background It has recently been found that both nuclear epithelial-expressed histone
deacetylases Hdac1 and Hdac2 are important to insure intestinal homeostasis and control …

Lipoxygenases catalyze the oxidation of unsaturated fatty acids, such as linoleic acid, which
play a crucial role in inflammatory responses. Selective inhibitors may provide a new …

Epithelial-derived thymic stromal lymphopoietin (TSLP) plays an important role in
pathogenesis in several types of dermatitis. Recently, the anti-inflammatory effects of aryl …

Pancreatic ductal adenocarcinoma (PDAC) is quite resistant to conventional treatments, and
gemcitabine, the standard chemotherapeutic agent, offers only a small benefit. Development …

Abstract Background Steroid insensitivity in Chronic Obstructive Pulmonary Disease (COPD)
presents a problem for controlling the chronic inflammation of the airways. The …

The properties of a cell are determined both genetically by the DNA sequence of its genes
and epigenetically through processes that regulate the pattern, timing and magnitude of …

Abstract EP300 and CBP (KAT3A/3B) are two highly homologous, multidomain, epigenetic
coregulators that play central roles in transcription through the acetylation of lysine residues …

As rates of obesity soar in the Unites States and around the world, cancer attributed to
obesity has emerged as a major threat to public health. The link between obesity and cancer …