Exercise is a complex cardiovascular, respiratory and musculoskeletal interaction which
facilitates energy transformation. The UK Cystic Fibrosis (CF) Trust recommends that …

Purpose Cerebral hypoxia may exacerbate the perception of fatigue. We previously
demonstrated that exercise-related hypoxemia, a hallmark of fibrotic interstitial lung disease …

Introduction Cardiopulmonary exercise testing (CPET) quantitates and qualitates the
integrated physiological response of a person to incremental exercise and provides …

Background Exercise testing is important in people with cystic fibrosis (pwCF). The aim was
to develop an incremental maximal step test to assess exercise capacity across the range of …

Heightened sensation of leg effort contributes importantly to poor exercise tolerance in
patient populations. We aim to provide a sex‐and age‐adjusted frame of reference to judge …

Background Evaluation of unexplained exercise intolerance is best resolved by
cardiopulmonary exercise testing (CPET) which enables the determination of the exercise …

Abstract Background: Post-COVID-19 exercise intolerance is poorly understood.
Cardiopulmonary exercise testing (CPET) can identify the underlying exercise limitations …

Purpose: Exercise intolerance, evaluated by O 2 consumption, predicts mortality in Cystic
Fibrosis (CF). People with CF exhibit skeletal muscle dysfunctions that may contribute to an …

Activity-related dyspnea in chronic lung disease is centrally related to dynamic (dyn)
inspiratory constraints to tidal volume expansion. Lack of reference values for exertional …

Backgound Increasing evidence suggests that vitamin D is associated with pulmonary
health, which may benefit children and young people diagnosed with Cystic Fibrosis …