Understanding cancer biology and the development of novel agents for cancer treatment
has always been the goal of cancer researchers. However, the research and development of …

Advances in next-generation sequencing technologies have generated the data supporting
a large volume of somatic alterations in several national and international cancer genome …

The repurposing of drugs is becoming increasingly attractive as it avoids the lengthy process
and cost implications associated with bringing a novel drug to market. Itraconazole is a …

Itraconazole, a common triazole anti-fungal drug in widespread clinical use, has evidence of
clinical activity that is of interest in oncology. There is evidence that at the clinically relevant …

Itraconazole (ITZ) is an anti-fungal drug that has been used in clinical practice for nearly 35
years. Recently, numerous experiments have shown that ITZ possesses anti-cancer …

Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest tumors
worldwide. The diagnosis is often possible only in the latter stages of the disease, with …

Background: The evolutionarily conserved Hedgehog (Hh) signaling cascade is one of the
key mediators of embryonic development of many metazoans. This pathway has been …

Although polymeric micelles of paclitaxel (PTX) significantly reduce excipient‐induced
toxicity compared with Taxol, they exhibit few clinical advantages in tumor inhibition and …

The treatment of advanced basal cell carcinoma has seen a progressive evolution in recent
years following the introduction of Hedgehog pathway inhibitors. However, given the burden …

Itraconazole is an FDA‐approved antifungal agent, which has been reported to possess
promising anticancer activities in recent years. This study investigates the antiproliferative …