Myeloid cells, including antigen-presenting cells (APCs) and myeloid-derived suppressor
cells (MDSCs) play opposing roles to orchestrate innate and adaptive immune responses …

Abstract T regulatory (Treg)/T-helper (Th) 17 imbalance has been shown to integrate with
epigenetics to result in the development of autoimmune diseases. We aim to investigate the …

DNA methylation as a process that regulates gene expression is crucial in immune cells
biology. Global and gene specific methylation changes have been described in …

Background Genome-wide association studies (GWASs) have identified dozens of loci
associated with gout, but for most cases, the risk genes and the underlying molecular …

Background Late-onset asthma (LOA) is beginning to account for an increasing proportion of
asthma patients, which is often underdiagnosed in the elderly. Studies on the possible …

Although lupus is, by definition, associated with genetic and immunological factors, its
molecular mechanisms remain unclear. The up-to-date research findings point out that …

Autoimmune encephalitis (AE) is a severe neurological disease. The brain of the AE patient
is attacked by a dysregulated immune system, which is caused by the excessive production …

Multiple sclerosis (MS) is an aggravating autoimmune disease that cripples young patients
slowly with physical, sensory and cognitive deficits. The break of self-tolerance to neuronal …

Background: Dysregulated DNA methylation in lymphocytes has been linked to autoimmune
disorders. The aims of this study were to identify global DNA methylation patterns in patients …

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of
the central nervous system that involves several not yet fully elucidated pathophysiologic …