DNA methylation in the promoters of PD-L1, MMP9, ARG1, galectin-9, TIM-3, VISTA and TGF-β genes in HLA-DR– myeloid cells, compared with HLA-DR+ antigen …
Myeloid cells, including antigen-presenting cells (APCs) and myeloid-derived suppressor
cells (MDSCs) play opposing roles to orchestrate innate and adaptive immune responses …
cells (MDSCs) play opposing roles to orchestrate innate and adaptive immune responses …
Decipher manifestations and Treg/Th17 imbalance in multi-staging rheumatoid arthritis and correlation with TSDR/RORC methylation
Y Huang, H Wang, X Ba, Z Chen, Y Wang, K Qin… - Molecular …, 2020 - Elsevier
Abstract T regulatory (Treg)/T-helper (Th) 17 imbalance has been shown to integrate with
epigenetics to result in the development of autoimmune diseases. We aim to investigate the …
epigenetics to result in the development of autoimmune diseases. We aim to investigate the …
DNA methylation changes on immune cells in systemic lupus erythematosus
C Hurtado, LY Acevedo Saenz… - …, 2020 - Taylor & Francis
DNA methylation as a process that regulates gene expression is crucial in immune cells
biology. Global and gene specific methylation changes have been described in …
biology. Global and gene specific methylation changes have been described in …
[HTML][HTML] DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A …
Z Zhu, W Meng, P Liu, X Zhu, Y Liu, H Zou - Clinical epigenetics, 2017 - Springer
Background Genome-wide association studies (GWASs) have identified dozens of loci
associated with gout, but for most cases, the risk genes and the underlying molecular …
associated with gout, but for most cases, the risk genes and the underlying molecular …
[HTML][HTML] The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma
L Yuan, L Wang, X Du, L Qin, M Yang, K Zhou… - Journal of Translational …, 2020 - Springer
Background Late-onset asthma (LOA) is beginning to account for an increasing proportion of
asthma patients, which is often underdiagnosed in the elderly. Studies on the possible …
asthma patients, which is often underdiagnosed in the elderly. Studies on the possible …
DNA methylation alterations in the pathogenesis of lupus
SH Chen, QL Lv, L Hu, MJ Peng… - Clinical & …, 2017 - academic.oup.com
Although lupus is, by definition, associated with genetic and immunological factors, its
molecular mechanisms remain unclear. The up-to-date research findings point out that …
molecular mechanisms remain unclear. The up-to-date research findings point out that …
[HTML][HTML] S100A6 promotes B lymphocyte penetration through the blood–brain barrier in autoimmune encephalitis
Autoimmune encephalitis (AE) is a severe neurological disease. The brain of the AE patient
is attacked by a dysregulated immune system, which is caused by the excessive production …
is attacked by a dysregulated immune system, which is caused by the excessive production …
Epigenetics in multiple sclerosis
VSF Chan - Epigenetics in allergy and autoimmunity, 2020 - Springer
Multiple sclerosis (MS) is an aggravating autoimmune disease that cripples young patients
slowly with physical, sensory and cognitive deficits. The break of self-tolerance to neuronal …
slowly with physical, sensory and cognitive deficits. The break of self-tolerance to neuronal …
Alterations of global DNA methylation and DNA methyltransferase expression in T and B lymphocytes from patients with newly diagnosed autoimmune thyroid …
Q Guo, D Wu, H Yu, J Bao, S Peng, Z Shan, H Guan… - Thyroid, 2018 - liebertpub.com
Background: Dysregulated DNA methylation in lymphocytes has been linked to autoimmune
disorders. The aims of this study were to identify global DNA methylation patterns in patients …
disorders. The aims of this study were to identify global DNA methylation patterns in patients …
[HTML][HTML] Deciphering the role of DNA methylation in multiple sclerosis: emerging issues
M Sokratous, E Dardiotis, Z Tsouris, E Bellou… - Autoimmunity …, 2016 - Springer
Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of
the central nervous system that involves several not yet fully elucidated pathophysiologic …
the central nervous system that involves several not yet fully elucidated pathophysiologic …