Do Environmental Fluoride Exposure and ESRα Genetic Variation Modulate Methylation Modification on Bone Changes in Chinese Farmers?

Y Zhang, H Huang, B Gong, L Duan… - Chemical Research …, 2017 - ACS Publications
Although increasing evidence suggests that estrogen receptor α (ESRα) genetic variation
could modify bone damage caused by environmental fluoride exposure, little is known about …

Methylation Status of the miR-141-3p Promoter Regulates miR-141-3p Expression, Inflammasome Formation, and the Invasiveness of HTR-8/SVneo Cells

D Wu, L Shi, F Chen, Q Lin, J Kong - Cytogenetic and Genome …, 2022 - karger.com
Abstract MicroRNA-141 (miR-141-3p) is upregulated in preeclampsia. This study
investigated the effect of methylation of the miR-141-3p promoter on cell viability, invasion …

Iodine excess did not affect the global DNA methylation status and DNA methyltransferase expression in T and B lymphocytes from NOD. H-2h4 and Kunming mice

Q Guo, D Wu, C Fan, S Peng, H Guan, Z Shan… - International …, 2018 - Elsevier
Dysregulated DNA methylation in lymphocytes has been linked to various autoimmune
disorders. Excessive iodine intake leads to lymphocyte dysfunction and contributes to …

MIRACLE: Multi-task Learning based Interpretable Regulation of Autoimmune Diseases through Common Latent Epigenetics

P Xu, J Cai, Y Gao, Z Rong - arXiv preprint arXiv:2306.13866, 2023 - arxiv.org
DNA methylation is a crucial regulator of gene transcription and has been linked to various
diseases, including autoimmune diseases and cancers. However, diagnostics based on …

Epigenetic Profiles Reveal That ADCYAP1 Serves as Key Molecule in Gestational Diabetes Mellitus

X Li, W Yang, Y Fang - Computational and Mathematical …, 2019 - Wiley Online Library
Gestational diabetes mellitus (GDM) refers to the condition which shows abnormal glucose
metabolism that occurs during pregnancy, while normal glucose metabolism before …

[PDF][PDF] Profiling of DNA methylation patterns as biomarkers of human disease

V Modhukur - Tartu, Estonia: Tartu University.[Google Scholar], 2019 - core.ac.uk
Deoxyribonucleic acid (DNA) forms the blueprint of life, wherein the genetic information
required for the growth and development of organism is stored. Epigenetics deals with the …

表观遗传药物在结直肠癌治疗中的研究进展

朱波, 刘经纬, 豆建, 李日恒 - 医学研究与教育, 2020 - yxyjyjy.hbu.edu.cn
结直肠癌(colorectal cancer, CRC) 是常见的消化道恶性肿瘤之一, 其患病率和病死率均呈逐年
上升趋势, 严重威胁人类健康. 结直肠癌的表型演变经历了腺瘤-腺癌两个阶段, 其发生 …

Construction of a questionnaire to characterize environmental exposures in patients with systemic lupus erythematosus

C Hurtado, D Rojas-Gualdrón, D Hernández… - Revista Colombiana de …, 2021 - Elsevier
Introduction As the knowledge of systemic lupus erythematosus (SLE) advances, the need to
characterize the burden of environmental exposure in patients becomes increasingly …

Analysis of the epigenetic regulation of TNF receptor superfamily 25 (TNFRSF25) in rheumatoid arthritis

B Golbargi, A Najafi, S Mastury, F Golbargi - Gene Reports, 2019 - Elsevier
Epigenetic changes in certain genes have been shown to strongly contribute to the
development of Rheumatoid Arthritis (RA) and the behavior of involved cell types …

[PDF][PDF] DNA 甲基化与口腔疾病的研究进展

原振英, 管翠强, 南欣荣 - 收藏, 2019 - jcme.org.cn
DNA 甲基化现在被广泛认为是维持免疫细胞功能的关键. 异常的DNA 甲基化水平与常见的口腔
疾病相关. 环境因素和遗传多态性导致甲基化异常, 影响某些免疫相关基因的表达 …