▪ Abstract Several members of the tumor necrosis factor receptor (TNFR) family function after
initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB …

The past decade has revealed that melanoma is comprised of multiple subclasses that can
be categorized on the basis of key features, including the clinical stage of disease, the …

Advances in our understanding of the regulatory mechanisms of the immune system have
led to the development of novel approaches for cancer therapy, including inhibition of …

Functionally barricaded immune responses or sites of immune privilege are no longer
considered dependent on specific anatomical considerations, but rather, they can develop in …

5,166.320 A 11/1992 Wu et al. 5, 190,878 A 3, 1993 Wilhelm 5,529,921 A 6, 1996 Peterson
et al. 5,827,642 A 10, 1998 Riddell et al. 5,858,358 A 1/1999 June et al. 5,888,807 A 3, 1999 …

Autoimmune diseases constitute a heterogeneous group of disorders with one common
feature–the loss of immune tolerance towards autoantigens. Due to the complexity of the …

Lymphodepletion with chemotherapeutic agents or total body irradiation (TBI) before
adoptive transfer of tumor-specific T cells is a critical advancement in the treatment of …

Cytokines mediate key communication pathways essential for regulation of immune
responses. Full activation of antigen‐responding lymphocytes requires cooperating signals …

Chronic lymphocytic leukemia (CLL) B cells become sensitive to Fas (CD95)–mediated
apoptosis 3 to 5 days after CD40 ligation. However, CD4+ cytotoxic T lymphocytes (CTLs) …

Chimeric Antigen Receptor-T cells (CAR-T) are considered novel biological agents,
designed to selectively attack cancer cells expressing specific antigens, with demonstrated …