Epidemiological and phenomenological studies suggest shared underpinnings between
multiple addictive behaviors. The present genetic association study was conducted as part …

Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …

Dysfunction of brain resting-state functional networks has been widely reported in
psychiatric disorders. However, the causal relationships between brain resting-state …

Substance use disorders (SUDs) remain a significant public health challenge, affecting tens
of millions of individuals worldwide each year. Often comorbid with other psychiatric …

Cannabis and related compounds have created significant research interest as a promising
therapy in many disorders. However, the individual therapeutic effects of cannabinoids and …

Background Do genetic risk profiles for drug use disorder (DUD), major depression (MD),
and attention-deficit hyperactivity disorder (ADHD) differ substantially as a function of sex …

Importance Although hypothesis-driven research has identified several factors associated
with psychosis, this one-exposure-to-one-outcome approach fails to embrace the multiplicity …

Background and Objectives: Evidence indicates that mood disorders often co-occur with
substance-related disorders. However, pooling comorbidity estimates can be challenging …

Observational studies suggest that physical activity can reduce the risk of mental health and
substance use disorders. However, it is unclear whether this relationship is causal or …