Rapid Diagnosis of Drug-Resistant Tuberculosis–Opportunities and Challenges

K Naidoo, R Perumal, SL Ngema, L Shunmugam… - Pathogens, 2023 - mdpi.com
Global tuberculosis (TB) eradication is undermined by increasing prevalence of emerging
resistance to available drugs, fuelling ongoing demand for more complex diagnostic and …

Diagnosis of extrapulmonary tuberculosis by GeneXpert MTB/RIF Ultra assay

B Dahiya, N Mehta, A Soni… - Expert Review of Molecular …, 2023 - Taylor & Francis
Introduction Diagnosis of extrapulmonary tuberculosis (EPTB) is an arduous task owing to
different anatomical locations, unusual clinical presentations, and sparse bacillary load in …

Evaluation of Xpert MTB/XDR test for susceptibility testing of Mycobacterium tuberculosis to first and second-line drugs in Uganda

A Katamba, W Ssengooba, J Sserubiri, D Semugenze… - PLoS …, 2023 - journals.plos.org
Background Drug-Resistant Tuberculosis (DR-TB) is one of the major challenges to TB
control. Design and methods This was a blinded, laboratory-based cross-sectional study …

Microfluidic systems for infectious disease diagnostics

T Lehnert, MAM Gijs - Lab on a Chip, 2024 - pubs.rsc.org
Microorganisms, encompassing both uni-and multicellular entities, exhibit remarkable
diversity as omnipresent life forms in nature. They play a pivotal role by supplying essential …

Effect of mixed Mycobacterium tuberculosis infection on rapid molecular diagnostics among patients starting MDR-TB treatment in Uganda

K Komakech, L Nakiyingi, A Fred, B Achan… - BMC Infectious …, 2024 - Springer
Abstract Background Mixed M. tuberculosis (MTB) infection occurs when one is infected with
more than one clonally distinct MTB strain. This form of infection can assist MTB strains to …

Quantification of mycobacterial proteins in extrapulmonary tuberculosis cases by nano-based real-time immuno-PCR

B Dahiya, T Prasad, A Rais, A Sheoran… - Future …, 2023 - Taylor & Francis
Aim: Diagnosis of extrapulmonary tuberculosis (EPTB) is difficult, and a rapid and
dependable diagnostic test is urgently needed. Methods: A nano-based assay, SYBR Green …

Assess the Diagnostic Accuracy of GeneXpert to Detect Mycobacterium tuberculosis and Rifampicin-Resistant Tuberculosis among Presumptive Tuberculosis and …

V Ramachandra, U Brammacharry, A Muralidhar… - Microbiology …, 2023 - mdpi.com
GeneXpert MTB/RIF is a rapid molecular diagnostic tool capable of simultaneously detecting
Mycobacterium tuberculosis and rifampicin resistance. This study aimed to assess the …

Decoding drug resistance in mycobacterium tuberculosis complex: genetic insights and future challenges

A Deshpande, R Likhar, T Khan… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction Tuberculosis (TB), particularly its drug-resistant forms (MDR-TB and XDR-TB),
continues to pose a significant global health challenge. Despite advances in treatment and …

Drug-Resistant Tuberculosis and COVID-19: A Scoping Review on a New Threat to Antimicrobial Resistance

BPM Silva, AS Almeida, MGM Sérgio… - Revista Brasileira de …, 2023 - SciELO Brasil
Objective: To assess the impact of COVID-19 on the morbidity and mortality associated with
drug-resistant tuberculosis (DR-TB). Methods: A comprehensive review of articles published …

[HTML][HTML] Innovative COVID-19 Point-of-Care Diagnostics Suitable for Tuberculosis Diagnosis: A Scoping Review

LML Holtgrewe, S Jain, R Dekova, T Broger… - Journal of Clinical …, 2024 - mdpi.com
Rapid and accurate point-of-care (POC) tuberculosis (TB) diagnostics are crucial to bridge
the TB diagnostic gap. Leveraging recent advancements in COVID-19 diagnostics, we …