[HTML][HTML] Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

[HTML][HTML] Molecular regulations of circadian rhythm and implications for physiology and diseases

F Fagiani, D Di Marino, A Romagnoli… - Signal transduction and …, 2022 - nature.com
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of …

G Mancia, R Kreutz, M Brunström, M Burnier… - Journal of …, 2023 - journals.lww.com
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

[HTML][HTML] Circadian disruption and human health

AB Fishbein, KL Knutson, PC Zee - The Journal of clinical …, 2021 - Am Soc Clin Investig
Circadian disruption is pervasive and can occur at multiple organizational levels,
contributing to poor health outcomes at individual and population levels. Evidence points to …

[HTML][HTML] Genomics of circadian rhythms in health and disease

F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

[HTML][HTML] The relevance of daylight for humans

A Wirz-Justice, DJ Skene, M Münch - Biochemical pharmacology, 2021 - Elsevier
Daylight is ubiquitous and is crucial for mammalian vision as well as for non-visual input to
the brain via the intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the …

Circadian rhythms, disease and chronotherapy

Y Lee, JM Field, A Sehgal - Journal of biological rhythms, 2021 - journals.sagepub.com
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

[HTML][HTML] Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy

FA Lévi, A Okyar, E Hadadi… - Annual review of …, 2024 - annualreviews.org
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

[HTML][HTML] Foundations of circadian medicine

A Kramer, T Lange, C Spies, AM Finger, D Berg… - PLoS …, 2022 - journals.plos.org
The circadian clock is an evolutionarily highly conserved endogenous timing program that
structures physiology and behavior according to the time of day. Disruption of circadian …

[HTML][HTML] Circadian rhythms and astrocytes: the good, the bad, and the ugly

MH Hastings, M Brancaccio… - Annual review of …, 2023 - annualreviews.org
This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …