Re-engineering extracellular vesicles as smart nanoscale therapeutics

JPK Armstrong, MN Holme, MM Stevens - ACS nano, 2017 - ACS Publications
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …

Tetraspanins: host factors in viral infections

CS New, ZY Lee, KS Tan, AHP Wong… - International Journal of …, 2021 - mdpi.com
Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as
host factors in infectious diseases. In particular, they were implicated in the pathogenesis of …

Development of exosome surface display technology in living human cells

Z Stickney, J Losacco, S McDevitt, Z Zhang… - … and biophysical research …, 2016 - Elsevier
Surface display technology is an emerging key player in presenting functional proteins for
targeted drug delivery and therapy. Although a number of technologies exist, a desirable …

Genetically engineered cellular membrane vesicles as tailorable shells for therapeutics

E Ren, C Liu, P Lv, J Wang, G Liu - Advanced Science, 2021 - Wiley Online Library
Benefiting from the blooming interaction of nanotechnology and biotechnology, biosynthetic
cellular membrane vesicles (Bio‐MVs) have shown superior characteristics for therapeutic …

Pseudotyping exosomes for enhanced protein delivery in mammalian cells

C Meyer, J Losacco, Z Stickney, L Li… - International journal of …, 2017 - Taylor & Francis
Exosomes are cell-derived nanovesicles that hold promise as living vehicles for intracellular
delivery of therapeutics to mammalian cells. This potential, however, is undermined by the …

Targeting of tetraspanin CD81 with monoclonal antibodies and small molecules to combat cancers and viral diseases

C Bailly, X Thuru - Cancers, 2023 - mdpi.com
Simple Summary Novel therapeutic targets are needed to improve treatments of aggressive
cancers and viral diseases. Tetraspanins represent an emerging class of anticancer targets …

Exosomal tetraspanins as regulators of cancer progression and metastasis and novel diagnostic markers

RR Malla, S Pandrangi, S Kumari… - Asia‐Pacific Journal …, 2018 - Wiley Online Library
Exosomes are cell–cell communicators emerging as a new paradigm for noninvasive
diagnosis and prognosis of treatment response. Exosomal tetraspanin proteins like CD63 …

Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies

S Detchokul, ED Williams, MW Parker… - British journal of …, 2014 - Wiley Online Library
One of the hallmarks of cancer is the ability to activate invasion and metastasis. Cancer
morbidity and mortality are largely related to the spread of the primary, localized tumour to …

Bifidobacterium bifidum PRL2010 modulates the host innate immune response

F Turroni, V Taverniti, P Ruas-Madiedo… - Applied and …, 2014 - Am Soc Microbiol
Here, we describe data obtained from transcriptome profiling of human cell lines and
intestinal cells of a murine model upon exposure and colonization, respectively, with …

Tetraspanins-gateways for infection

PN Monk, LJ Partridge - Infectious Disorders-Drug Targets …, 2012 - ingentaconnect.com
The tetraspanins constitute a conserved superfamily of four-span membrane proteins that
are widely distributed in multi-cellular organisms. A characteristic property of tetraspanins is …