Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …

Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …

Autophagy is an intracellular bulk degradation system that is highly conserved in
eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly …

Aspergillus fumigatus is a ubiquitous mold that can cause severe infections in
immunocompromised patients, typically manifesting as invasive pulmonary aspergillosis …

Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …

Dysregulated inflammasome activation contributes to respiratory infections and pathologic
airway inflammation. Through basic and translational approaches involving murine models …

NADPH oxidase (NOX) isoforms together have multiple functions that are important for
normal physiology and have been implicated in the pathogenesis of a broad range of …

Patients with chronic granulomatous disease (CGD) have a mutated NADPH complex
resulting in defective production of reactive oxygen species; these patients can develop …

Autophagy and immunity share the property of being auto-protective for the organism.
Autophagy is an important degradation pathway that buffers nutrient deprivation by recycling …