In voltage-dependent potassium channels, the molecular determinants of ion selectivity are
found in the P (pore) region, a stretch of 21 contiguous residues. Cysteine was introduced at …

The binding site in G-protein-linked neurotransmitter receptors is formed among their
membrane-spanning segments. Because the binding site is in the plane of the bilayer and is …

Arginine 347 in the sixth transmembrane domain of cystic fibrosis transmembrane
conductance regulator (CFTR) is a site of four cystic fibrosis-associated mutations. To better …

Ionic selectivity in many cation channels is achieved over a short region of the pore known
as the selectivity filter, the molecular determinants of which have been identified in Ca 2+ …

The cystic fibrosis transmembrane conductance regulator (CFTR) protein forms a Cl−
channel found in the plasma membranes of many epithelial cells, including those of the …

P-glycoprotein (P-gp; ABCB1) actively transports a broad range of structurally unrelated
compounds out of the cell. An important step in the transport cycle is coupling of drug …

The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the
ATP-binding cassette (ABC) transporter superfamily that functions as an ATP-gated channel …

To explore aqueous accessibility and functional contributions of transmembrane domain
(TM) 1 in human serotonin transporter (hSERT) proteins, we utilized the largely …

The goal of the experiments described here was to explore the possible role of fixed charges
in determining the conduction properties of CFTR. We focused on transmembrane segment …

Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR), a member of the ATP-binding cassette (ABC) family of membrane …