To explore the relationship between structure and function in the cystic fibrosis
transmembrane conductance regulator (CFTR) Cl-channel, we studied Xenopus CFTR. We …

The identification and characterization of the CFTR gene and protein have provided not only
a major impetus to the dissection of the molecular pathophysiology of cystic fibrosis (CF) but …

Over 1,500 cystic fibrosis transmembrane conductance regulator (CFTR) gene sequence
variations have been identified in patients with cystic fibrosis (CF) and related disorders …

The 110-amino acid multidrug transporter from E. coli, EmrE, is a member of the family of
MiniTexan or Smr drug transporters. EmrE can transport acriflavine, ethidium bromide …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel with
distinctive kinetics. At the whole-cell level, CFTR currents in response to voltage steps are …

The structure and transport mechanism of paracellular pores are only poorly understood.
Here we describe for the first time how the substituted cysteine accessibility method (SCAM) …

In a previous study of T338C CFTR (cystic fibrosis transmembrane conductance regulator)
we found that protons and thiol-directed reagents modified channel properties in a manner …

The use of methanethiosulfonates as thiol-specific modifying reagents in the strategy of
combined site-directed mutagenesis and chemical modification allows virtually unlimited …

μ-Conotoxin (μ-CTX) specifically occludes the pore of voltage-dependent Na+ channels. In
the rat skeletal muscle Na+ channel (μ1), we examined the contribution of charged residues …

We have identified a cDNA, PGT, that encodes a widely expressed transporter for
prostaglandin (PG) E 2, PGF 2α, PGD 2, 8-iso-PGF 2α, and thromboxane B 2. To begin to …