BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology …

We conducted a genome-wide association study for testicular germ cell tumor (TGCT),
genotyping 307,666 SNPs in 730 cases and 1,435 controls from the UK and replicating …

miR-122, a hepato-specific microRNA (miRNA), is frequently down-regulated in human
hepatocellular carcinoma (HCC). In an effort to identify novel miR-122 targets, we performed …

Abstract Klinefelter syndrome (47, XXY) is characterized by small, firm testis, gynaecomastia,
azoospermia and hypergonadotropic hypogonadism. Degeneration of the seminiferous …

One of the most effective ways to combat different types of cancer is through early diagnosis
and administration of effective treatment, followed by efficient monitoring that will allow …

The BCL-2 family of proteins integrates signals that trigger either cell survival or apoptosis.
The balance between pro-survival and pro-apoptotic proteins is important for tissue …

Dysregulation of male germ cell apoptosis has been associated with the pathogenesis of
male infertility. Therefore, factors involved in the regulation of germ cell death are being …

The purpose of the present study was to examine the possible involvement of caspase-3
and caspase-activated deoxyribonuclease in rat testicular germ cell apoptosis resulting from …

For normal spermatogenesis, the temperature of the scrotum is lower than that of the body.
The mechanism by which mammalian testes undergoes cell death as the result of exposure …