Iron accumulation has been associated with the etiology and progression of multiple
neurodegenerative diseases (NDDs). The exact role of iron in these diseases is not fully …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that
affect millions of people worldwide, with both prevalence and incidence increasing with age …

Oxytosis/ferroptosis is an iron-dependent oxidative form of cell death triggered by lethal
accumulation of phospholipid hydroperoxides (PLOOHs) in membranes. Failure of the …

Ferroptosis is a newly identified form of non-apoptotic programmed cell death, characterized
by the iron-dependent accumulation of lethal lipid reactive oxygen species (ROS) and …

Ferroptosis, a regulated form of cell death, is characterized by iron-dependent lipid
peroxidation leading to oxidative damage to cell membranes. Cell sensitivity to ferroptosis is …

Ferroptosis, a mode of cell death that was recently identified in 2012, is driven by iron-
dependent lipid peroxidation and distinct from other mechanisms of cell death such as …

Glioma, the most common primary malignant tumor of the central nervous system, lacks
effective targeted therapies. This study investigates the role of SOAT1, a key gene involved …

Ferroptosis is a recently recognized form of cell death with distinct features in terms of
morphology, biochemistry, and molecular mechanisms. Unlike other types of cell death …

Despite considerable research efforts, it is still not clear which mechanisms underlie
neuronal cell death in neurodegenerative diseases. During the last 20 years, multiple …

The design of clinical protocols and the selection of drugs with appropriate posology are
critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be …