Genetically modified swine hold great promise in the fields of agriculture and medicine.
Currently, these swine are being used to optimize production of quality meat, to improve our …

The in vitro production of porcine embryos has presented numerous challenges to
researchers over the past four decades. Some of the problems encountered were specific to …

We recently derived mouse expanded potential stem cells (EPSCs) from individual
blastomeres by inhibiting the critical molecular pathways that predispose their differentiation …

Zinc-finger nucleases (ZFNs) are powerful tools for producing gene knockouts (KOs) with
high efficiency. Whereas ZFN-mediated gene disruption has been demonstrated in …

Xenotransplantation from pigs could alleviate the shortage of human tissues and organs for
transplantation. Means have been identified to overcome hyperacute rejection and acute …

Contents In the last decade, the research community has witnessed a blooming of targeted
genome editing tools and applications. Novel programmable DNA nucleases such as zinc …

Background Xenotransplantation is considered to be a promising solution to the growing
demand for suitable donor organs for transplantation. Despite tremendous progress in the …

In recent years, significant progress has been achieved in genome editing applications
using new programmable DNA nucleases such as zinc finger nucleases (ZFNs) …

The birth of “Dolly,” the first mammal cloned from an adult mammary epithelial cell,
abolished the decades-old scientific dogma implying that a terminally differentiated cell …

Oropeza M, Petersen B, Carnwath JW, Lucas‐Hahn A, Lemme E, Hassel P, Herrmann D,
Barg‐Kues B, Holler S, Queisser A‐L, Schwinzer R, Hinkel R, Kupatt C, Niemann H …