Whole-genome sequencing (WGS) of pathogens is becoming increasingly important not
only for basic research but also for clinical science and practice. In virology, WGS is …

Background The numerically most abundant biological entities on Earth are viruses. Vast
populations prey on the cellular microbiota in all habitats, including the human gut. Main …

The characterization of the blood virome is important for the safety of blood-derived
transfusion products, and for the identification of emerging pathogens. We explored non …

Human blood metagenomics has revealed the presence of different types of viruses in
apparently healthy subjects. By far, anelloviruses constitute the viral family that is more …

Until recently, the method of choice to characterize viral diversity consisted in cloning PCR
amplicons of full-length viral genomes and Sanger-sequencing of multiple clones. However …

Metagenomics is greatly improving our ability to discover new viruses, as well as their
possible associations with disease. However, metagenomics has also changed our …

Blood transfusion safety is an essential element of public health. Current blood screening
strategies rely on targeted techniques that could miss unknown or unexpected pathogens …

BACKGROUND Although the risk of transmitting infectious agents by blood transfusion is
dramatically reduced after donor selection, leukoreduction, and laboratory testing, some …

Usually transmitted via respiratory droplets, parvovirus B19 (B19V) can also be acquired by
blood transfusion especially because of viral persistence, resistance to blood treatment …

Early detection of pathogens at the point of care helps reduce the threats to human and
animal health from emerging pathogens. Initially, the disease-causing agent will be …