[HTML][HTML] Translation potential and challenges of in vitro and murine models in cancer clinic
Y Long, B Xie, HC Shen, D Wen - Cells, 2022 - mdpi.com
As one of the leading causes of death from disease, cancer continues to pose a serious
threat to human health globally. Despite the development of novel therapeutic regimens and …
threat to human health globally. Despite the development of novel therapeutic regimens and …
[HTML][HTML] DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC
Y Wang, L Ju, G Wang, K Qian, W Jin, M Li, J Yu… - Nature …, 2023 - nature.com
To date, most studies on the DNA polymerase, POLD1, have focused on the effect of POLD1
inactivation mutations in tumors. However, the implications of high POLD1 expression in …
inactivation mutations in tumors. However, the implications of high POLD1 expression in …
Conditional reprogramming: Modeling urological cancer and translation to clinics
W Liu, L Ju, S Cheng, G Wang, K Qian… - Clinical and …, 2020 - Wiley Online Library
Patient‐derived models, including cell models (organoids and conditionally reprogrammed
cells [CRCs]) and patient‐derived xenografts, are urgently needed for both basic and …
cells [CRCs]) and patient‐derived xenografts, are urgently needed for both basic and …
Long-lasting proteinaceous nanoformulation for tumor imaging and therapy
L Zhao, X Gu, F Jiang, B Li, S Lu, F Wang, Y Sun… - ACS …, 2022 - ACS Publications
Nanodrugs have attracted increasing interest in drug delivery and disease treatment.
However, the cumbersome preparation process and the poor biocompatibility of nanodrugs …
However, the cumbersome preparation process and the poor biocompatibility of nanodrugs …
肿瘤生物模型及其功能性检测的转化潜能和应用
花威， 毕臻乐， 林琳， 胡凯猛， 闻丹忆 - 药学进展, 2023 - pps.cpu.edu.cn
分子靶向治疗和免疫治疗在不同类型的肿瘤中均显示出疗效, 已成为肿瘤治疗的新兴领域和方向
. 二维和三维细胞培养模型, 基因工程小鼠模型, 类器官模型, 患者来源的异种移植瘤(PDX) …
. 二维和三维细胞培养模型, 基因工程小鼠模型, 类器官模型, 患者来源的异种移植瘤(PDX) …
A novel germline EGFR variant p. R831H causes predisposition to familial CDK12-mutant prostate cancer with tandem duplicator phenotype
K Qian, G Wang, L Ju, J Liu, Y Luo, Y Wang, T Peng… - Oncogene, 2020 - nature.com
10% of total prostate cancer (PCa) cases are hereditary. Particularly, immune checkpoint
inhibitor-sensitive tandem duplicator phenotype (TDP) accounts for 6.9% of PCa cases …
inhibitor-sensitive tandem duplicator phenotype (TDP) accounts for 6.9% of PCa cases …
[HTML][HTML] 分化可控的人类鼻粘膜类器官模型的建立
汪珂， 于言， 韩日， 王显文， 赵云腾… - Journal of Southern …, 2022 - ncbi.nlm.nih.gov
分化可控的人类鼻粘膜类器官模型的建立- PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …
Establishment of a culture system for human nasal mucosa organoids with controllable differentiation
K Wang, Y Yu, R Han, X Wang, Y Zhao… - Nan Fang yi ke da xue …, 2022 - europepmc.org
Objective To establish a culture system for human nasal mucosal organoids with
controllable differentiation to reproduce the structure and function of the source tissue …
controllable differentiation to reproduce the structure and function of the source tissue …