Post-transcriptional gene regulation by mRNA modifications
The recent discovery of reversible mRNA methylation has opened a new realm of post-
transcriptional gene regulation in eukaryotes. The identification and functional …
transcriptional gene regulation in eukaryotes. The identification and functional …
What are 3′ UTRs doing?
C Mayr - Cold Spring Harbor perspectives in biology, 2019 - cshperspectives.cshlp.org
SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
[PDF][PDF] Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis
and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here …
and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here …
[PDF][PDF] N6-methyladenosine modulates messenger RNA translation efficiency
Summary N 6-methyladenosine (m 6 A) is the most abundant internal modification in
mammalian mRNA. This modification is reversible and non-stoichiometric and adds another …
mammalian mRNA. This modification is reversible and non-stoichiometric and adds another …
Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
H Shi, P Chai, R Jia, X Fan - Molecular cancer, 2020 - Springer
RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms …
necessary reactions, and these modifications play roles in essential molecular mechanisms …
A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus
Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes
including atherosclerosis. Using RNA-seq profiling of the intima of lesions, here we identify a …
including atherosclerosis. Using RNA-seq profiling of the intima of lesions, here we identify a …
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
D Dominissini, S Moshitch-Moshkovitz, S Schwartz… - Nature, 2012 - nature.com
An extensive repertoire of modifications is known to underlie the versatile coding, structural
and catalytic functions of RNA, but it remains largely uncharted territory. Although …
and catalytic functions of RNA, but it remains largely uncharted territory. Although …
Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation
A Valinezhad Orang, R Safaralizadeh… - … journal of genomics, 2014 - Wiley Online Library
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
CD Marceau, AS Puschnik, K Majzoub, YS Ooi… - Nature, 2016 - nature.com
The Flaviviridae are a family of viruses that cause severe human diseases. For example,
dengue virus (DENV) is a rapidly emerging pathogen causing an estimated 100 million …
dengue virus (DENV) is a rapidly emerging pathogen causing an estimated 100 million …
[HTML][HTML] Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells
Y Chen, C Pan, X Wang, D Xu, Y Ma, J Hu, P Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Since primary prostate cancer (PCa) can advance to the life-threatening
metastatic PCa, exploring the molecular mechanisms underlying PCa metastasis is crucial …
metastatic PCa, exploring the molecular mechanisms underlying PCa metastasis is crucial …