Elimination of tissue viral reservoirs is likely the key to generation of an effective HIV cure.
Exciting studies have come out recently that reveal crucial insights into topics ranging from …

This review outlines the neuropathogenesis of HIV, from initial HIV entry into the central
nervous system (CNS) to chronic infection, focusing on key advancements in the last 5 …

HIV-specific chimeric antigen receptor–T cell (CAR T cell) therapies are candidates to
functionally cure HIV infection in people with HIV (PWH) by eliminating reactivated HIV …

A major roadblock to achieving a cure for human immunodeficiency virus type one (HIV-1) is
the persistence of latent viral infections in the cells and tissue compartments of an infected …

Human Immunodeficiency virus (HIV)-associated neurocognitive disorders are a major
burden for people living with HIV whose viremia is stably suppressed with antiretroviral …

While modern HIV therapy can effectively suppress viral replication, the persistence of the
latent reservoir posits the greatest hurdle to complete cure. The “shock and kill” strategy is …

Chimeric Antigen Receptor (CAR) T cell therapies are tremendously successful in
hematological malignancies and show great promise as treatment and curative strategy for …

Adoptive cell therapy (ACT) using T cells expressing chimeric antigen receptors (CARs) is
an area of intense investigation in the treatment of malignancies and chronic viral infections …

HIV-specific T cells are necessary for control of HIV-1 replication but are largely insufficient
for viral clearance. This is due in part to these cells' recognition of immunodominant but …

Non-human primate (NHP) models are important for vaccine development and also
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …