Tight junctions (TJ) are cell–cell adhesive structures that define the permeability of barrier-
forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a …

Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by
autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg) 1 …

Cadherins mediate cell–cell adhesion through a dynamic process that is strongly dependent
on the cellular context and signaling. Cadherin regulation reflects the interplay between …

We suggest that the human body can be viewed as of textile nature whose fabric consists of
interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which …

Globally, cancer is a major catastrophic disease that seriously threatens human health.
Thus, there is an urgent need to find new strategies to treat cancer. Among them, identifying …

Desmosome diseases are caused by dysfunction of desmosomes, which anchor
intermediate filaments (IFs) at sites of cell–cell adhesion. For many decades, the focus of …

Cancer relapse and metastasis are major obstacles for effective treatment. One important
mechanism to eliminate cancer cells is to induce apoptosis. Activation of executioner …

Melanoma is an aggressive cancer typically arising from transformation of melanocytes
residing in the basal layer of the epidermis, where they are in direct contact with surrounding …

To improve wound healing or treatment of other skin diseases, and provide model cells for
skin biology studies, in vitro differentiation of stem cells into keratinocyte-like cells (KLCs) is …

While classic cadherin-actin connections in adherens junctions (AJs) have ancient origins,
intermediate filament (IF) linkages with desmosomal cadherins arose in vertebrate …