Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …

Cardiac fibrosis (CF), a process characterized by potentiated proliferation of cardiac
fibroblasts and excessive secretion and deposition of extracellular matrix (ECM) from the …

The available evidence suggests a complex relationship between diabetes and cancer.
Epidemiological data suggest a positive correlation, however, in certain types of cancer, a …

The aberrant activation of complement system in several kidney diseases suggests that this
pillar of innate immunity has a critical role in the pathophysiology of renal damage of …

The thymus is a critical immune organ with endocrine and immune functions that plays
important roles in the physiological and pathological processes of the body. However, with …

Endothelial mesenchymal transition (EndMT) has been described as a fundamental process
during embryogenesis; however, it can occur also in adult age, underlying pathological …

The myocardium consists of different cell types, of which endothelial cells, cardiomyocytes,
and fibroblasts are the most abundant. Communication between these different cell types …

An in-depth understanding of the mechanisms underlying EndMT or the acquisition of a
profibrotic secretory phenotype by endothelial cells will provide the rationale for novel …

Mancozeb (MZ), an antibacterial pesticide, has been linked to reproductive toxicity,
neurotoxicity, and endocrine disruption. However, whether MZ has cardiactoxicity is unclear …

The primary function of the endothelial cells (EC) lining the inner surface of all vessels is to
regulate permeability of vascular walls and to control exchange between circulating blood …