Endothelial-tumor cell interaction in brain and CNS malignancies

M Peleli, A Moustakas, A Papapetropoulos - International journal of …, 2020 - mdpi.com
Glioblastoma and other brain or CNS malignancies (like neuroblastoma and
medulloblastoma) are difficult to treat and are characterized by excessive vascularization …

A dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition

C Savorani, M Malinverno, R Seccia… - Journal of Cell …, 2021 - journals.biologists.com
Endothelial-to-mesenchymal transition (EndMT) is the biological process through which
endothelial cells transdifferentiate into mesenchymal cells. During embryo development …

The role of endothelial progenitors in the repair of vascular damage in systemic sclerosis

N Del Papa, F Pignataro - Frontiers in Immunology, 2018 - frontiersin.org
Systemic sclerosis (SSc) is a connective tissue disease characterized by a complex
pathological process where the main scenario is represented by progressive loss of …

Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly

H Toba, ML Lindsey - Pharmacology & therapeutics, 2019 - Elsevier
Whereas hypertension, diabetes, and dyslipidemia are age-related risk factors for
cardiovascular disease (CVD) and chronic kidney disease (CKD), aging alone is an …

Endothelial-specific loss of IFT88 promotes endothelial-to-mesenchymal transition and exacerbates bleomycin-induced pulmonary fibrosis

S Singh, M Adam, PN Matkar, A Bugyei-Twum… - Scientific Reports, 2020 - nature.com
Abstract Intraflagellar transport protein 88 (Ift88) is required for ciliogenesis and shear stress-
induced dissolution of cilia in embryonic endothelial cells coincides with endothelial-to …

Oxidative storm induced by tryptophan metabolites: missing link between atherosclerosis and chronic kidney disease

I Kwiatkowska, JM Hermanowicz… - Oxidative Medicine …, 2020 - Wiley Online Library
Chronic kidney disease (CKD) occurrence is rising all over the world. Its presence is
associated with an increased risk of premature death from cardiovascular disease (CVD) …

Role of HIF‐1α in pathogenic mechanisms of keloids

Z Qiu, M Zhang, W Zhang, Z Li, L Si… - Journal of Cosmetic …, 2023 - Wiley Online Library
Abstract Backgrouds and Objective Keloids are defined as overrepairing products that
develop after skin lesions. Keloids are characterized by the proliferation of fibroblasts and …

Perspectives of PDE inhibitor on treating idiopathic pulmonary fibrosis

X Yang, Z Xu, S Hu, J Shen - Frontiers in Pharmacology, 2023 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD)
without an identifiable cause. If not treated after diagnosis, the average life expectancy is 3 …

TFPI2 suppresses the interaction of TGF-β2 pathway regulators to promote endothelial–mesenchymal transition in diabetic nephropathy

G Guan, J Xie, Y Dai, H Han - Journal of Biological Chemistry, 2022 - ASBMB
Endothelial–mesenchymal transition (EndMT) is an important source of myofibroblasts, but
also contributes to the progression of diabetic nephropathy (DN). By several differential …

Endothelial-to-mesenchymal transition in atherosclerosis: friend or foe?

S Gole, S Tkachenko, T Masannat, RA Baylis… - Cells, 2022 - mdpi.com
Despite many decades of research, complications of atherosclerosis resulting from the
rupture or erosion of unstable plaques remain the leading cause of death worldwide …